NEW YORK (PIX11) — Hundreds of women who used Depo-Provera and later developed brain tumors are suing Pfizer.
Miller & Zois, Attorneys at Law, is one of the few firms interviewing women who have received at least two injections of Depo-Provera and were later diagnosed with a meningioma, a noncancerous brain tumor.
A website set up for women considering joining the class-action lawsuit cites new studies showing evidence that Depo-Provera can cause meningiomas.
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Multiple studies found in the National Institutes of Health, Drexel University, and the British Medical Journal have found that prolonged use of the drug may be associated with meningioma.
“Women should be cautioned about the prolonged use of [Medroxyprogesterone Acetate],” states one study. “Future research should examine whether the extended use of [Medroxyprogesterone Acetate] is associated with the meningioma grade.”
What is Depo-Provera?
Depo-Provera, or medroxyprogesterone acetate, is a birth control shot administered every three months. It’s used to prevent pregnancy and manage menstrual cycle-related conditions. Health care professionals may recommend it for women who prefer not to take daily pills, as well as for off-label uses like treating anemia, seizures, sickle cell disease, endometriosis, or uterine fibroids, according to the Mayo Clinic.
How many women have come forward?
As of late September 2025, more than 1,300 lawsuits have been filed through the multidistrict litigation process, a procedure in federal courts that consolidates multiple cases.
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How much money could potentially be paid out?
Miller & Zois acknowledges that it is still early, but estimates that individual settlements could range from $275,000 to over $1.5 million.
Who qualifies for the lawsuit?
Women who have received at least two injections of Depo-Provera and were later diagnosed with a meningioma brain tumor may have a strong legal claim, Miller & Zois.
Women who used Depo-Provera for five years or more have a more compelling argument.
NewsNation affiliate WPIX reached out to ask if a meningioma was listed on the insert as a possible list of adverse side effects for the drug. Pfizer did not comment.
The company issued the following statement regarding the lawsuit:
“Depo-Provera has been an FDA-approved medication for more than 30 years and has been a safe and effective treatment option for millions of patients during that time. The company will vigorously defend these lawsuits.”
